Wickramasinghe, S.N.: BLOOD AND BONE MARROW PATHOLOGY; October 2002; 300,00 €; 704 Pag. / 1130 Illus.

 
S N Wickramasinghe, Emeritus Professor of Haematology in the University of London, Visiting Professor of Haematology, University of Oxford, Formerly Head of the Department of Haematology, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London UK.  
Dr Jeffrey McCullough , Professor, Director, Division of Laboratory Medicine, Section of Transfusion Medicine University of Minnesota Medical School, Minneapolis, USA.  

 
 
The most complete and authoritative benchside reference text on the pathological interpretation and diagnosis of blood and bone marrow disease.  
 
This new title covers all of the pathological conditions that are likely to be encountered in daily practice such as anaemias, bleeding and coagulation disorders, leukaemias. Completely revised from cover to cover, it incorporates the latest knowledge on the molecular basis of inherited red cell and coagulation disorders.  
 
The book is generously illustrated with high quality colours images depicted throughout. For ease of use, each chapter has been organised into a consistent format, giving details of incidence/epidemiology, pathogenesis, brief clinical presentation, histological and cytological appearance, testing techniques and diagnosis. There is also a section on clinical behaviour and possible outcomes.  

 

Features
  • Detailed descriptions of the pathological features of blood and bone marrow in combination with over 1,000 high quality illustrations provide the reader with a single, comprehensive resource to assist in accurate diagnosis.
  • Histological and cytological appearances are correlated throughout to provide the reader with a complete and integrated approach to diagnostic interpretation and reporting.
  • An emphasis on differential diagnosis and diagnostic pitfalls provides the reader with a quick, practical solution to reporting difficult and problematic specimens.
  • Focus on the practical techniques of diagnostic laboratory testing reflects the realities of the pathologist's everyday work environment.
  • Consistent and logical organisational structure will enable the reader to locate essential information quickly and easily.

 
Contents
 
Section 1: Normal blood and bone marrow cells and hematopoiesis  
Normal blood cells  
Normal bone marrow cells: Development, cytology and ultrastructure  
Normal bone marrow: histology, histochemistry and immunohistochemistry  
Regulation of hematopoiesis  
 
Section 2: Pathology of the marrow  
General considerations  
 
Section 3: Disorders affecting erythroid cells  
Investigation and classification of anaemia  
Abnormalities of the red cell membrane  
Inherited abnormalities of red cell enzymes  
Abnormalities of the structure and synthesis of haemoglobin  
Acquired haemolytic anaemias  
Iron deficiency anaemia, anaemia of chronic disorder and iron overload  
Macrocytic anaemia  
Aplastic anaemia  
Sideroblastic anaemias  
Congenital dyserythropoietic anaemias  
Polycythaemia (the erythrocytoses)  
 
Section 4: Disorders affecting leucocyte lineages  
Abnormalities in leucocyte morphology and number  
Disorders of phagocyte function  
Myelodysplastic disorders  
Acute leukaemias  
The chronic lymphoid and myeloid leukaemias and systemic mastocytosis  
Lymphoma 
Abnormalities in immunoglobulin synthesising cells  
 
Section 5: Abnormalities of hemostasis  
Hemostatis: Principles of investigation  
Disorders affecting megakaryocytes and platelets: inherited conditions  
Acquired disorders affecting megakaryocytes and platelets  
Inherited disorders of coagulation  
Acquired bleeding disorders  
Natural anticoagulants and thrombophilia  
 
Section 6: Immunohematology  
Blood groups on red cells, platelets and neutrophils  
Transfusion medicine for the pathologist  
Histocompatibility: HLA and other systems