Gene Therapy of Cancer 2E
Translational
Approaches from Preclinical Studies to Clinical Implementation
Edward C. Lattime, The Cancer
Institute of New Jersey, USA
Stanton L. Gerson, Case Western
Reserve University, USA
Offers
in a single volume, a comprehensive review of the rapidly changing field of gene
therapy of cancer. The basic biology of cancer and cancer immunology are
discussed, as are cancer targets including oncogenes, the cell cycle, induction
of apoptosis, drug resistance pathways, and tumour specific antigens. Chapters
emphasize the scientific basis of gene therapy, using immune, oncogene,
antisense, prodrug activating and drug resistance gene targets. Therapeutic
approaches and clinical applications are also covered.
Reviews
Review of First Edition:
"...offers a comprehensive
review of the rapidly evolving field of cancer gene therapy for basic,
translational, and clinical scientists. The editors have assembled a
distinguished group of academic contributors... Their insights into the progress
of cancer gene therapy and the challenges ahead are thoughtful and provocative."
- GYNECOLOGIC ONCOLOGY
Features
- Discusses
specific strategies for gene therapy intervention and current gene therapy
vehicles
Provides data demonstrating
clinical studies
Explains the requirements of
bringing new technologies to clinical use