Immunobiology 5

Immunobiology 5/e
The Immune System In Health And Disease

CA Janeway , Professor of Immunobiology, Yale University School of Medicine, USA
P Travers , Senior Scientist, Anthony Nolan Research Centre, London, UK
Professor M Walport , Chairman and Head, Division of Medicine, Imperial College School of Medicine, London, UK
M Shlomchik , Department of Laboratory Immunology, Yale University School of Medicine, USA

The central thesis of this book is that the immune system exists to protect the host from infection and that its evolutionary history was shaped by this challenge. Other aspects of immunology (for example allergy, graft rejection etc) are variations on the basic protective function. The first part of the book summarises the basic immunological concepts and introduces the main 'players'. The middle three parts deal with main aspects of adaptive immunity. The last part integrates the material at the level of the complete organism in both health and disease.

Superb four-colour line drawings depict the immunological processes. Each chapter end with an extensive list of references and further reading. The book ends with a 20 page glossary.

Written by just four main co-authors drawing on expert advice from many colleagues) the text has great consistency and cohesiveness.

Features

Two year edition cycle ensures this title is always up to date
Impressive four-colour illustrations throughout
Detailed scientific approach makes this the favourite for the `thinking' student

What's New

* Developments in the subject have led to a major reorganisation of the chapters
New chapter on Innate immunity and evolution
New co-author, Mark Shlomchik (Yale)
CD-ROM of animated illustrations
Adopter access to web site with all illustrations (Classwire)

Contents

Part I: An introduction to immunobiology and innate immunity

Basic concepts in immunology. Innate immunity.

Part II: The recognition of antigen

Antigen recognition by B and T cell receptors. The generation of Lymphocyte antigen receptors. Antigen presentation to T lymphocytes.

Part III: The development of mature lymphocyte receptor repertoires

Signaling through immune system receptors. The development and survival of lymphocytes.

Part IV: The adaptive immune response

T-cell mediated immunity. The humoral immune response. Adaptive immunity to infection.

Part V: The immune system in health and disease

Failure of host defense mechanisms. Allergy and hypersensitivityAutoimmunity and transplantation.. Manipulation of the immune response.

Part VI: Where the immune system came from and where is immunology going

Evolution

Appendices

The immunologists' toolbox. List of current CDs. Cytokines and their receptors. Chemokines and their receptors.