Chien, Kenneth: MOLECULAR BASIS OF CARDIOVASCULAR DISEASE. Companion Braunwald's heart disease

Año: 1998..........P.V.P. 32.500 Ptas/193,45 Euros..........592 Pag..........160 Illus.

Here's the first resource to comprehensively summarise today's greatly expanded knowledge about molecular cardiology. Over 50 international authorities provide up-to-date information on the molecular basis of heart disease and its clinical implications. They cover a full range of important topics in a manner that is straightforward and applicable to everyday practice

FEATURES:
  • Evaluates current topics such as: genetic mapping approaches in inherited cardiovascular disorders; driving mechanism in the transition from cardiac hypertrophy to heart failure, and second generation thrombolytic agents and their potential therapeutic advantages
  • Discusses clinical applications including: biologically targeted agents for hypertension and heart failure; new oral and i.v. drugs, and new anticoagulants, as well as the possibility of cardiovacular gene therapy in the future
  • Illustrates key concepts through abundant and detailed figures and tables
  • Provides a five-hundred-term glossary of molecular genetics that clarifies terms and concepts which may be unfamiliar to cardiologists

    • Referenced to the fifth Editon of Braunwald's Heart Disease, enabling readers to easily locate additional information on a full range of subjects

 CONTENTS:

Section I: Principles of Molecular cardiology. General principles of molecular biology. Genetic approaches to cardiovascular disease. Genetically modified animal models in cardiovascular research. Gene transfer approaches for cardiovascular disease. Section II: Morphogenesis and cardiovascular diseases. Molecular advances in cardiovascular development. Molecular genetics of congenital heart disease. Inherited vascular disease. Section III: Cardiac muscle and myopathies. Structure and function relationships in contractile proteins. Molecular and cellular biology of cardiac hyperthophy and failure. Gene defects of inherited cardiomyopathies. Mitochondrial genes in myopathy. Cardiomyopathy and stroke. Section IV: Cardiac conduction and arrhythmias. Normal cardiac electrophysiology. Molecular basis of inherited cardiac arrhythmias. Molecular approaches to arrhythomogenesis Section V: Vascular biology and atherogenesis. Biology of the vessel wall: Endothelium. Atherogenesis and inflammation. The molecular and cellular biology of coronary restenosis. Angiogenesis in cardiovascular disease. Section VI: Risk factors for coronary artery disease. Disorders of lipoprotein metabolism. Lipoprotein receptors and cellular cholesterol metabolism in health and disease. Lipoprotein oxidation, and atherogenesis. Molecular basis of non-insulin-dependent diabetes mellitus. Section VII: Molecular basis of hemostasis disorders. Blood coagulation in cardiovascular disease. The fibrinolytic system and thrombolytic therapy. Platelet thrombus formation and anti-platelet therapy.Glossary of molecular genetics