Section I: Epidemiology/clinical genetics/basic science

Chapter 1: Epidemiology

Chapter 2: Familial gliomas

Chapter 3: Neurofibromatosis and other phakomatoses

Chapter 4: Cytogenetics

Chapter 5: Molecular genetics

Chapter 6: Growth factor-mediated signaling pathways

Chapter 7: Glioma metabolism

Chapter 8: Tumor invasiveness

Chapter 9: Angiogenesis

Chapter 10: Peritumoral edema

Chapter 11: The blood-brain barrier: structure, function, and response to neoplasia

Section II: Experimental therapeutics

Chapter 12: Animal models of tumors of the nervous system

Chapter 13: Human glioma cultures and in vitro analysis of therapeutic response

Chapter 14: DNA repair-mediated resistance to alkylating agents

Chapter 15: Gene therapy for malignant brain tumors

Chapter 16: Antisense oligonucleotide targets

Section III: Pathology

Chapter 17: Classification

Chapter 18: Immunologic cell markers

Chapter 19: Cell kinetics

Chapter 20: Anatomy and growth patterns of diffuse gliomas

Chapter 21: Tumor makers in gliomas

Section IV. Diagnostic imaging

Chapter 22: Computed tomography

Chapter 23: Magnetic resonance imaging

Chapter 24: Positron emission tomography and 1H-spectroscopic imaging

Chapter 25: Single-photon emission computed tomography

Section V: Preoperative assessment and management

Chapter 26: Clinical presentation, evaluation, and preoperative preparation of the patient

Chapter 27: The role of functional imaging in the surgical management of brain neoplasms

Section VI: Resection strategies

Chapter 28: Positioning during glioma surgery

Chapter 29: Surgical approaches to gliomas

Chapter 30: Intraoperative localization of tumor and margins

Chapter 31: Closed biopsy techniques

Chapter 32: Computer-assited stereotactic laser resection

Chapter 33: Interactive image-guided surgical technology for glial tumor resection

Chapter 35: Tumor removal devices

Chapter 36: Closing procedures and postoperative care

Section VII: Treatment modalities

RADIOTHERAPY

Chapter 37: Basic principles of radiobiology and radiotherapy

Chapter 38: Issues in the use of conventional and altered fractionation radiation therapy for pediatric and adult gliomas

Chapter 39: Particle beam therapy

Chapter 40: Interstitial radiation and hyperthermia

Chapter 41: Radiosurgery

Chapter 42: Radiosensitizers

CHEMOTHERAPY

Chapter 43: Pharmacology of glioma therapy

Chapter 44: Intra-arterial chemotherapy ofr malignant gliomas

Chapter 45: High-dose chemotherapy followed by autologous bone marrow recue for high-grade gliomas

Chapter 46: Treatment of gliomas using polumer-drug delivery

Chapter 47: Intratumoral administration

Chapter 48: Hyperosmolar disruption of the blood-brain barrier as a chemotherapy potentiator in the treatment of brain tumors

IMMUNOTHERAPY

Chapter 49: Tumor immunobiology

Chapter 50: Biologic response modifiers

Chapter 51: Intracavitary immunotherapy

Chapter 52: Immunoconjugates

PHOTOTHERAPY

Chapter 53: Photodynamic therapy

Section VIII: Special topics

Chapter 54: Tumor dissemination and management

Chapter 55: Management of recurrent gliomas

Chapter 56: Extent of resection and outcome for cerebral hemispheric gliomas

Chapter 57: Gliomas in the very young child

Chapter 58: Childhood and adolescent gliomas

Chapter 59: Pregnancy and gliomas

Chapter 60: Clinical characteristics of long-term glioma survivors

Section IX: Treatment-Induced complications

Chapter 61: Radiation-induced tumors

Chapter 62: Central nervous system toxic effects of radiotherapy

Chapter 63: Cognitive deficits

Chapter 64: Endocrinologic dysfunction following adjunct tumor therapy

Chapter 65: Systemic sequelae of chemotherapy for gliomas

Chapter 66: Deep venous thrombosis and pulmonary embolism

Index